Supplement × Prescription·Evidence index
PubMed indexes 8 records that name Melatonin and Omeprazole together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.
A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.
Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.
“The combination of sublingual melatonin (3 mg/day) with omeprazole (20 mg/day) may be more effective than omeprazole (20 mg/day) alone in the treatment of gastroesophageal reflux disease.”
“Plasma ghrelin levels did not change significantly after treatment with melatonin or Trp, while plasma leptin increased significantly in patients treated with melatonin or Trp but not with placebo. We conclude that melatonin or Trp, when added to omeprazole treatment, accelerates ulcer healing and this likely depends mainly upon the significant increments in plasma melatonin.”
“Despite the fact that melatonin has a good safety profile, these findings raise concerns regarding the hepatotoxic potential of high doses of melatonin in polymedicated patients. This is attributed to a probable pharmacokinetic drug-drug interaction with concomitant medications sharing liver metabolization pathways with melatonin, leading to CYP450 metabolic pathways saturation.”
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
“The combination of sublingual melatonin (3 mg/day) with omeprazole (20 mg/day) may be more effective than omeprazole (20 mg/day) alone in the treatment of gastroesophageal reflux disease.”
Names both Melatonin and Omeprazole in its title.
“Plasma ghrelin levels did not change significantly after treatment with melatonin or Trp, while plasma leptin increased significantly in patients treated with melatonin or Trp but not with placebo. We conclude that melatonin or Trp, when added to omeprazole treatment, accelerates ulcer healing and this likely depends mainly upon the significant increments in plasma melatonin.”
Names both Melatonin and Omeprazole in its title.
Names both Melatonin and Omeprazole in its title.
“Intraperitoneal administration of alendronate did not cause much gastric irritation. Findings of the present study suggest that alendronate induces oxidative gastric damage by a local irritant effect and that melatonin and omeprazole are protective against this damage due to their antioxidant properties.”
Names both Melatonin and Omeprazole in its title.
“These findings suggest that active oxygene species and LPO have an important role in the pathogenesis of gastric mucosal damage induced by ASA and that both famotidine and omeprazole may be protective against this damage, although they were not as efficient as melatonin as an antioxidant. On the other hand, the antisecretory effect of omeprazole and famotidine may also be contributing to their antiulcer effect.”
Names both Melatonin and Omeprazole in its title.
“Moreover, in separate experiments, cotreatment of rats with melatonin and ranitidine or omeprazole was found to protect against stress ulceration in doses at which either of these alone could not protect the stomach. The findings raise the possibility of melatonin being considered as an effective gastroprotective agent individually or as a cotreatment with either ranitidine and omeprazole.”
Names both Melatonin and Omeprazole in its title.
“Despite the fact that melatonin has a good safety profile, these findings raise concerns regarding the hepatotoxic potential of high doses of melatonin in polymedicated patients. This is attributed to a probable pharmacokinetic drug-drug interaction with concomitant medications sharing liver metabolization pathways with melatonin, leading to CYP450 metabolic pathways saturation.”
Names Melatonin and Omeprazole together in an interaction, co-administration, or pharmacokinetic context.
Names Melatonin and Omeprazole together in an interaction, co-administration, or pharmacokinetic context.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Melatonin, Omeprazole, and several hundred other substances.
Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
