NutriStack
Melatonin and Omeprazole, a synergy.
Melatonin has gastroprotective and lower esophageal sphincter-tonifying effects and shows additive symptom relief when combined with omeprazole for GERD. In one randomized trial, melatonin plus omeprazole produced faster and more complete symptom resolution than omeprazole alone. Patients with mild reflux or who want to taper PPIs sometimes use melatonin as an adjunct.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Melatonin and Omeprazole
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Melatonin has gastroprotective and lower esophageal sphincter-tonifying effects and shows additive symptom relief when combined with omeprazole for GERD. In one randomized trial, melatonin plus omeprazole produced faster and more complete symptom resolution than omeprazole alone. Patients with mild reflux or who want to taper PPIs sometimes use melatonin as an adjunct.
Mechanism. Melatonin increases lower esophageal sphincter pressure, inhibits gastric acid and nitric oxide-mediated relaxation, and is mucosal-protective via antioxidant pathways. These effects are additive to omeprazole's blockade of the H+/K+-ATPase.
Recommendation. Discuss melatonin 3-6 mg at bedtime with your prescriber if you have ongoing reflux symptoms on omeprazole. Do not stop omeprazole abruptly without medical guidance, as rebound acid hypersecretion is common.
Sources (2)
- Kandil TS, Mousa AA, El-Gendy AA, Abbas AM. The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. BMC Gastroenterol. 2010;10:7. PMID 20082715
- Pereira RS. Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole. J Pineal Res. 2006;41(3):195-200. PMID 16948779
Stack Score
How this pair moves the number.
Effect on the composite score
If both Melatonin and Omeprazole are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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