From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveEmerging evidence
What is happening. Bulking fiber can delay absorption of oral drugs and dicyclomine can worsen constipation in some patients.
Mechanism. Fiber gel formation can physically delay drug dissolution and transit while anticholinergic therapy slows motility.
Recommendation. Separate psyllium and dicyclomine by at least 2 hours and increase fluids if fiber is used.
TimingTiming & separation.
Space the doses apart by at least this window to avoid the conflict.
Stack Score
How it moves the number.
Effect on the composite score
If both Dicyclomine and Psyllium Husk are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Lacy BE et al. ACG Clinical Guideline: Management of Irritable Bowel Syndrome. American Journal of Gastroenterology. 2021.Needs sourceNo link