Lithium/Carbamazepine and Psyllium Husk, a conflict.
Psyllium decreases oral bioavailability of carbamazepine and may reduce lithium levels via adsorption and delayed gastric emptying.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Lithium/Carbamazepine and Psyllium Husk
- Pair type
- Conflict
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Conflict · Moderate evidence
Conflict
What is happening. Psyllium decreases oral bioavailability of carbamazepine and may reduce lithium levels via adsorption and delayed gastric emptying.
Mechanism. Psyllium's viscous gel matrix adsorbs drugs and delays gastric emptying.
Recommendation. Take medications 2+ hours before or after psyllium.
Minimum separation. 120
Sources (1)
- Psyllium-lithium interaction PMID 1968148
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lithium/Carbamazepine and Psyllium Husk are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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