Interaction databaseSupplement × SupplementReviewed May 2026

Lithium/Carbamazepine and Psyllium Husk, a conflict.

Psyllium decreases oral bioavailability of carbamazepine and may reduce lithium levels via adsorption and delayed gastric emptying.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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At a glance

Substances
Lithium/Carbamazepine and Psyllium Husk
Pair type
Conflict
Evidence (highest tier)
Moderate
Source citations
1 source
Stack Score effect
−10 to your Stack Score (per scored conflict row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Conflict · Moderate evidence

Conflict

What is happening. Psyllium decreases oral bioavailability of carbamazepine and may reduce lithium levels via adsorption and delayed gastric emptying.

Mechanism. Psyllium's viscous gel matrix adsorbs drugs and delays gastric emptying.

Recommendation. Take medications 2+ hours before or after psyllium.

Minimum separation. 120

Sources (1)
  1. Psyllium-lithium interaction PMID 1968148

Stack Score

How this pair moves the number.

Effect on the composite score

If both Lithium/Carbamazepine and Psyllium Husk are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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