What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Doxycycline + Iron Bisglycinate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Doxycycline and Iron Bisglycinate, timing-sensitive.

Q: Can I take Doxycycline and Iron Bisglycinate together?

Yes, if you separate them in time. Doxycycline and Iron Bisglycinate have a documented timing-sensitive interaction. Iron bisglycinate, although marketed as a gentler chelated form, still releases iron in the gut that binds doxycycline and reduces its absorption dramatically. Classic kinetic studies show oral iron can cut doxycycline serum levels by 80 percent or more. The interaction is bidirectional: doxycycline absorption falls and iron absorption is also reduced.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Iron bisglycinate, although marketed as a gentler chelated form, still releases iron in the gut that binds doxycycline and reduces its absorption dramatically. Classic kinetic studies show oral iron can cut doxycycline serum levels by 80 percent or more. The interaction is bidirectional: doxycycline absorption falls and iron absorption is also reduced.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Doxycycline and Iron Bisglycinate
Pair type: Timing Sensitive
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored timing-sensitive row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Timing Sensitive · Strong evidence

Timing Sensitive

What is happening. Iron bisglycinate, although marketed as a gentler chelated form, still releases iron in the gut that binds doxycycline and reduces its absorption dramatically. Classic kinetic studies show oral iron can cut doxycycline serum levels by 80 percent or more. The interaction is bidirectional: doxycycline absorption falls and iron absorption is also reduced.

Mechanism. Iron chelates the beta-diketone system of tetracyclines, forming insoluble complexes that are not absorbed. Doxycycline also re-enters the gut via enterohepatic recirculation, where iron can re-chelate it.

Recommendation. Take doxycycline at least 2 hours before or 6 hours after iron bisglycinate. Do not take in the same dose.

Minimum separation. 360

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Doxycycline and Iron Bisglycinate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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