NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Calcium and Doxycycline: what the published research says

PubMed indexes 6 records that name Calcium and Doxycycline together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Doxycycline. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Calcium and Doxycycline.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Smartphone-assisted ratiometric fluorescence sensing platform for the detection of doxycycline based on BCNO QDs and calcium ion.

Mikrochimica acta · 2022 · PMID 35190913

“The application of smartphone and fluorescent test paper can effectively shorten the detection time and simplified the operation, providing an effective scheme for quantitative detection of doxycycline in actual samples. Overall, this work provides a method for the detection of doxycycline and shows that the BCNO QDs have great potential application in food safety.”

Liu et al. · From the abstract

Names both Calcium and Doxycycline in its title.

Characterization of doxycycline-loaded calcium phosphate cement: implications for treatment of aneurysmal bone cysts.

Journal of materials science. Materials in medicine · 2018 · PMID 29987657

Human subjects

“Ultimate stress significantly decreased between pre- and post-elution samples for 10 mg/mL (P= 0.001) and 15 mg/mL (P = 0.004) groups. This study demonstrated a dose-dependent response in ultimate strength and compressive modulus with addition of doxycycline to calcium phosphate cement.”

Daley et al. · From the abstract

Names both Calcium and Doxycycline in its title.

Loading and release of doxycycline hyclate from strontium-substituted calcium phosphate cement.

Acta biomaterialia · 2010 · PMID 19879982

“We can conclude that Sr substitution in secondary calcium phosphate cements improves their efficiency for DOXY-h adsorption and release. The antibiotic loading method provides a way to switch from rapid and complete to slower and prolonged drug release.”

Alkhraisat et al. · From the abstract

Names both Calcium and Doxycycline in its title.

Burden of enteral supplement interactions with common antimicrobial agents: a single-centre observational analysis.

European journal of hospital pharmacy : science and practice · 2022 · PMID 33414257

Observational StudyHuman subjects

“The concomitant administration of enteral calcium and iron with oral antimicrobials is common within the acute care hospital setting. Approximately one in five patients has a clinically important interaction which may impair oral bioavailability and limit treatment efficacy. As antimicrobial stewardship teams strive for increased intravenous-to-oral de-escalation, it is important that optimum dosing administration is followed to optimise patient outcomes.”

Hughes et al. · Authors' conclusion

Names Calcium and Doxycycline together in an interaction, co-administration, or pharmacokinetic context.

High-dose methotrexate-doxycycline interaction.

The Annals of pharmacotherapy · 1999 · PMID 10466909

Case ReportsHuman subjects

“The potential interaction between MTX and doxycycline may cause pharmacokinetic changes, and its clinical repercussions on the quality of life of the patient and associated costs should be considered.”

Tortajada-Ituren et al. · Authors' conclusion

Names Calcium and Doxycycline together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Doxycycline, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.