NutriStack
Estradiol and Maca Root, a caution.
Maca has been used for menopausal symptoms and sexual function with modest positive findings in small trials, and does not contain phytoestrogens. It is generally compatible with prescribed estradiol but is rarely needed and may complicate side-effect attribution.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Maca has been used for menopausal symptoms and sexual function with modest positive findings in small trials, and does not contain phytoestrogens. It is generally compatible with prescribed estradiol but is rarely needed and may complicate side-effect attribution.
Mechanism. Maca's clinical effects appear to be hormone-independent, acting via central monoaminergic and HPA-axis modulation rather than direct estrogen receptor binding. It does not measurably alter serum estradiol or FSH.
Recommendation. If menopausal symptoms persist on prescribed estradiol, maca 1.5-3 g/day may be tried with prescriber awareness. Maca does not raise serum estradiol, so dose adjustments are usually not needed.
Sources (2)
- Shin BC, Lee MS, Yang EJ, Lim HS, Ernst E. Maca (L. meyenii) for improving sexual function: a systematic review. BMC Complement Altern Med. 2010;10:44. PMID 20691074
- Basciani S, Porcaro G. Counteracting side effects of combined oral contraceptives through the administration of specific micronutrients. Eur Rev Med Pharmacol Sci. 2022;26(13):4846-4862. PMID 35856377
Stack Score
How this pair moves the number.
Effect on the composite score
If both Estradiol and Maca Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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