NutriStack
HMB and Vitamin D3, a synergy.
Vitamin D supports muscle function and the response to HMB, with combined supplementation showing greater gains in muscle strength and quality, particularly in older or deficient adults.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- HMB and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Vitamin D supports muscle function and the response to HMB, with combined supplementation showing greater gains in muscle strength and quality, particularly in older or deficient adults.
Mechanism. Vitamin D acts on muscle vitamin D receptors to support protein synthesis and fiber function, which appears to enhance the anabolic and anti-catabolic effects of HMB on muscle.
Recommendation. Reasonable to combine, especially if vitamin D status is low; check and correct vitamin D levels for best muscle response.
Sources (2)
- Fuller JC et al., Vitamin D status affects strength gains in older adults supplemented with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and lysine, JPEN Journal of Parenteral and Enteral Nutrition, 2011
- Stout JR et al., Effect of calcium beta-hydroxy-beta-methylbutyrate (CaHMB) with and without resistance training in men and women 65+ years, Experimental Gerontology, 2013
Stack Score
How this pair moves the number.
Effect on the composite score
If both HMB and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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