What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Krill Oil + Warfarin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Krill Oil and Warfarin, a caution.

Q: Can I take Krill Oil and Warfarin together?

Possibly, but with caution. Krill Oil and Warfarin have a documented caution-tier interaction. Krill oil contains the same omega-3 fatty acids (EPA and DHA) as fish oil, which reduce platelet thromboxane A2 and may prolong bleeding time. The omega-3 content per gram is lower than concentrated fish oil, so the interaction is generally weaker, but at higher doses krill oil can add pharmacodynamic bleeding risk to warfarin.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Krill oil contains the same omega-3 fatty acids (EPA and DHA) as fish oil, which reduce platelet thromboxane A2 and may prolong bleeding time. The omega-3 content per gram is lower than concentrated fish oil, so the interaction is generally weaker, but at higher doses krill oil can add pharmacodynamic bleeding risk to warfarin.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Krill Oil and Warfarin
Pair type: Caution
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Krill oil contains the same omega-3 fatty acids (EPA and DHA) as fish oil, which reduce platelet thromboxane A2 and may prolong bleeding time. The omega-3 content per gram is lower than concentrated fish oil, so the interaction is generally weaker, but at higher doses krill oil can add pharmacodynamic bleeding risk to warfarin.

Mechanism. EPA and DHA from krill oil displace arachidonic acid in platelet membranes, reducing thromboxane A2 generation and platelet aggregation. They may also slightly reduce factor VII activity. These pharmacodynamic effects add to warfarin's reduction of clotting factor synthesis.

Recommendation. If you take krill oil with warfarin, keep the dose constant (typically 500-1000 mg/day) and tell your anticoagulation clinic. Avoid combining krill oil with fish oil or other omega-3 sources, and watch for unusual bruising or bleeding.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Krill Oil and Warfarin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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