Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats.
Animal study
Names both Vitamin K2 MK-4 and Warfarin in its title.
Supplement × Prescription·Evidence index
PubMed indexes 5 records that name Vitamin K2 MK-4 and Warfarin together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Vitamin K2 MK-4 and Warfarin. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
Names both Vitamin K2 MK-4 and Warfarin in its title.
“(S) (-)-Warfarin and (R) (+)-warfarin isomers inhibited the biosynthesis of menaquinone-4 of about 67 and 17 per cent respectively. Fractionation of soluble microsomal proteins lead to the the isolation of a menaquinone-4 binding protein.”
Names both Vitamin K2 MK-4 and Warfarin in its title.
Names both Vitamin K2 MK-4 and Warfarin in its title.
“A 74-year-old female patient with bladder cancer presented with edema in the right lower limb in a follow-up at the outpatient department.She was diagnosed with deep vein thrombosis in the right lower limb, and warfarin treatment was started.Subsequent gemcitabine and cisplatin combination(GC)therapy for prevention of bladder cancer recurrence prolonged the PT-INR to an immeasurable level on day 6 of therapy.Thus, warfarin was immediately discontinued and a single dose of…”
Names Vitamin K2 MK-4 and Warfarin together in an interaction, co-administration, or pharmacokinetic context.
Names Vitamin K2 MK-4 and Warfarin together in an interaction, co-administration, or pharmacokinetic context.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Vitamin K2 MK-4, Warfarin, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.