NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Coenzyme Q10 and Warfarin: what the published research says

PubMed indexes 4 records that name Coenzyme Q10 and Warfarin together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Coenzyme Q10 and Warfarin. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Coenzyme Q10 and Warfarin.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Effect of coenzyme Q10 on warfarin hydroxylation in rat and human liver microsomes.

Current drug metabolism · 2005 · PMID 15853759

Comparative StudyHuman subjects

“In both species, CoQ(10) had enzyme activation effect, which appeared to be regioselective but not stereoselective, on the formation of the phenolic metabolites of warfarin enantiomers. A moderate increase in the total clearance of warfarin enantiomers could occur with coadministration of CoQ(10)in humans.”

Zhou et al. · From the abstract

Names both Coenzyme Q10 and Warfarin in its title.

Interaction between warfarin and coenzyme Q10

Ugeskrift for laeger · 1998 · PMID 9621803

Case ReportsHuman subjects

“Patients in treatment with warfarin should be aware of the possible risk of treatment failure when taking coenzyme Q10. The need for questioning patients concerning not only medications but also use of dietary supplements and alternative medications is emphasised.”

Landbo et al. · From the abstract

Names both Coenzyme Q10 and Warfarin in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Coenzyme Q10, Warfarin, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.