NutriStack
Glucosamine and Warfarin, a caution.
21 spontaneous reports of increased INR with glucosamine use in WHO database.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Glucosamine and Warfarin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. 21 spontaneous reports of increased INR with glucosamine use in WHO database.
Mechanism. Unknown, not via CYP enzyme inhibition.
Recommendation. Monitor INR more frequently when starting or stopping glucosamine in warfarin patients.
Sources (4)
- Glucosamine-warfarin interaction reports PMID 18363538
- Warfarin + glucosamine-chondroitin PMID 15237575
- Zhu X, Sang L et al.. Combined glucosamine and chondroitin for osteoarthritis: A systematic review and meta-analysis.. Rheumatology. 2024. PMID 40300556
- Wang M, Zeraatkar D, Obeda M, Lee M et al.. Drug-drug interactions with warfarin: A systematic review and meta-analysis. British Journal of Clinical Pharmacology. 2021. PMID 33769581
Stack Score
How this pair moves the number.
Effect on the composite score
If both Glucosamine and Warfarin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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