NutriStack
L-Methionine and Vitamin B12, a synergy.
Methionine is recycled from homocysteine via B12-dependent methionine synthase; adequate B12 is required to handle methionine load without raising homocysteine.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Methionine and Vitamin B12
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Methionine is recycled from homocysteine via B12-dependent methionine synthase; adequate B12 is required to handle methionine load without raising homocysteine.
Mechanism. B12 is the cofactor for methionine synthase, which remethylates homocysteine back to methionine. Without it, methionine intake raises homocysteine.
Recommendation. Pair methionine supplementation with adequate B12, folate, and B6. Test homocysteine to confirm methylation is supported.
Sources (1)
- Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Methionine and Vitamin B12 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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