NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Colchicine and Vitamin B12: what the published research says

PubMed indexes 4 records that name Colchicine and Vitamin B12 together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Colchicine and Vitamin B12. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Colchicine and Vitamin B12.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Vitamin B12 levels in familial Mediterranean fever patients treated with colchicine.

Clinical and experimental rheumatology · 2013 · PMID 24064015

Human subjects

“We did not observe significant vitamin B12 deficiency among colchicine-treated FMF patients but some cases may be more prone to developing this potentially serious disorder.”

Gemici et al. · Authors' conclusion

Names both Colchicine and Vitamin B12 in its title.

Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor.

Gastroenterology · 1979 · PMID 759260

Animal study

“Histologic examination of the ileal mucosa showed a decrease in the population of villus cells after colchicine. The correlation between the changes in receptor quantity and in vivo B12-absorption prove that the IF-B12 receptor is a critical limiting factor in B12 absorption.”

Stopa et al. · From the abstract

Names both Colchicine and Vitamin B12 in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Colchicine, Vitamin B12, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.