What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Trimethylglycine + Vitamin B12 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Moderate evidence

Trimethylglycine + Vitamin B12

Q: Can I take Trimethylglycine and Vitamin B12 together?

Yes. The combination of Trimethylglycine and Vitamin B12 produces a measurable benefit. Adequate B12 ensures the methionine synthase pathway functions, so that methyl groups from both folate and betaine are used efficiently and methionine produced by TMG is not diverted. B12 status influences the overall methylation benefit of betaine.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Moderate evidence

Adequate B12 ensures the methionine synthase pathway functions, so that methyl groups from both folate and betaine are used efficiently and methionine produced by TMG is not diverted. B12 status influences the overall methylation benefit of betaine.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Trimethylglycine and Vitamin B12

Pair type

Synergy

Evidence

Moderate

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyModerate evidence

What is happening. Adequate B12 ensures the methionine synthase pathway functions, so that methyl groups from both folate and betaine are used efficiently and methionine produced by TMG is not diverted. B12 status influences the overall methylation benefit of betaine.

Mechanism. Vitamin B12 is the cofactor for methionine synthase, the folate-dependent remethylation enzyme that operates in parallel with betaine-dependent BHMT.

Recommendation. Ensure B12 sufficiency when using TMG for homocysteine or methylation support, particularly in older adults or those with low B12 intake.

Stack Score

How it moves the number.

Effect on the composite score

If both Trimethylglycine and Vitamin B12 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999.Needs sourceNo link

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Open the interaction checker → Browse the research index