What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Trimethylglycine + Zinc pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Emerging evidence

Trimethylglycine + Zinc

Q: Can I take Trimethylglycine and Zinc together?

Yes. The combination of Trimethylglycine and Zinc produces a measurable benefit. Zinc is the catalytic metal cofactor for betaine-homocysteine methyltransferase (BHMT), the enzyme through which TMG donates its methyl group to homocysteine. Adequate zinc status supports the efficiency of TMG-driven remethylation.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Emerging evidence

Zinc is the catalytic metal cofactor for betaine-homocysteine methyltransferase (BHMT), the enzyme through which TMG donates its methyl group to homocysteine. Adequate zinc status supports the efficiency of TMG-driven remethylation.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Trimethylglycine and Zinc

Pair type

Synergy

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyEmerging evidence

What is happening. Zinc is the catalytic metal cofactor for betaine-homocysteine methyltransferase (BHMT), the enzyme through which TMG donates its methyl group to homocysteine. Adequate zinc status supports the efficiency of TMG-driven remethylation.

Mechanism. BHMT is a zinc-dependent metalloenzyme; zinc coordinates homocysteine binding in the active site during methyl transfer from betaine.

Recommendation. Maintain adequate zinc intake when relying on TMG for homocysteine lowering. No special dose timing is required.

Stack Score

How it moves the number.

Effect on the composite score

If both Trimethylglycine and Zinc are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Evans JC, et al. Betaine-homocysteine methyltransferase: zinc in a thiolate-containing active site. Proc Natl Acad Sci USA. 2002.Needs sourceNo link

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