Fish Oil and Trimethylglycine: what the published research says
PubMed indexes 8 records that name Fish Oil and Trimethylglycine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Fish Oil and Trimethylglycine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.
The research
8 studies naming Fish Oil and Trimethylglycine.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
“In addition, betaine's antioxidant properties reduce oxidative stress and improve immune signaling, helping fish maintain optimal immune function even in stressful environments. This comprehensive review aims to investigate the multifaceted role of betaine in improving fish immunity and antioxidant responses and the mechanisms associated with these roles.”
Names both Fish Oil and Trimethylglycine in its title.
“Additionally, betaine supplementation tended to store the energy storage as hepatic glycogen. Our findings proposed the possible mechanism for appetite regulation through autophagy via AMPK/mTOR, and demonstrated the feasibility of betaine as an aquafeed additive to regulate appetite and intermediary metabolism in fish.”
Names both Fish Oil and Trimethylglycine in its title.
“Overall, dietary betaine improved growth, attenuated HC-diet-induced oxidative stress and ER stress, and ultimately alleviated apoptosis in mandarin fish. These findings provide evidence for the use of betaine in aquafeeds to counter disruptive effects due to diets containing high carbohydrate levels.”
Names both Fish Oil and Trimethylglycine in its title.
Journal of microbiology (Seoul, Korea) · 2017 · PMID 28035596
Animal study
“These findings confirmed that glycine betaine serves as an effective cold stress protectant and highlighted an underappreciated facet of the acclimatization of V. anguillarum to cold environments.”
Names both Fish Oil and Trimethylglycine in its title.
Biochimica et biophysica acta · 2016 · PMID 27036080
Animal study
“Data on bhmt3 gene expression and promoter activity evidences a novel function for betaine-homocysteine S-methyltransferase in bone and cartilage development, while phylogenetic analysis provides new insights into the evolution of vertebrate BHMTs and suggests that multiple gene duplication events occurred in neoteleost fish lineage.”
Names both Fish Oil and Trimethylglycine in its title.
“Since a treatment of Salmonella with glycine betaine before the bacteria was exposed to CMBA resulted in inhibition of the mutagenesis, the antimutagenic action of glycine betaine may be taking place inside the cells. These observations suggest that the mutagenic action of CMBA may be modified by the presence of both extracellular and intracellular glycine betaine.”
Names both Fish Oil and Trimethylglycine in its title.
“We have established a pan-European reference metabolome for urine and serum of healthy children and gathered critical resources not previously available for future investigations into the influence of the metabolome on child health. The six European cohort populations studied share common metabolic associations with age, sex, BMI z-score and main dietary habits. Furthermore, we have identified a novel metabolic association between threonine catabolism and BMI of children.”
Names Fish Oil and Trimethylglycine together in an interaction, co-administration, or pharmacokinetic context.
Limitations
What this evidence cannot tell you.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.
Nearby evidence
Other pairs with published research.
Pages covering Fish Oil or Trimethylglycine alongside a different substance.
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Fish Oil, Trimethylglycine, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
