NutriStack
Vitamin B12 and Vitamin B6, a synergy.
B6, B12, and folate work together to metabolize homocysteine. All three are needed for optimal methylation.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Vitamin B12 and Vitamin B6
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. B6, B12, and folate work together to metabolize homocysteine. All three are needed for optimal methylation.
Mechanism. B6 (as PLP) is cofactor for cystathionine beta-synthase (transsulfuration pathway). B12 for methionine synthase (remethylation). Both pathways clear homocysteine.
Recommendation. Take B6, B12, and folate together for comprehensive homocysteine management and methylation support.
Sources (1)
- Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999
Stack Score
How this pair moves the number.
Effect on the composite score
If both Vitamin B12 and Vitamin B6 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.