Supplement researchSourced from PubMed and NIH
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Supplement × Prescription·Evidence index

Isoniazid and Vitamin B6: what the research found

PubMed indexes 8 records that name Isoniazid and Vitamin B6 together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“Here, we report a case of isoniazid-induced psychosis in a 4-year-old girl. The purpose of this report is to sensitise the paediatric healthcare community regarding this rare clinical entity along with highlighting the putative role of pyridoxine supplementation in the management of isoniazid-induced psychosis.”

Yadav et al. · 2022 · Human study · details

“The reported frequency of INH-induced neuropathy in various studies is reviewed and population groups at relatively high risk of developing this complication are identified. The routine use of pyridoxine supplementation to prevent peripheral neuropathy in high risk populations is recommended.”

The research

8 studies naming Isoniazid and Vitamin B6.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Pyridoxine in isoniazid-induced psychosis.

Sudanese journal of paediatrics · 2022 · PMID 36875946

Case Reports

“Here, we report a case of isoniazid-induced psychosis in a 4-year-old girl. The purpose of this report is to sensitise the paediatric healthcare community regarding this rare clinical entity along with highlighting the putative role of pyridoxine supplementation in the management of isoniazid-induced psychosis.”

Yadav et al. · From the abstract

Names both Isoniazid and Vitamin B6 in its title.

Isoniazid and pyridoxine.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1993 · PMID 8221474

CommentLetterHuman subjects

Names both Isoniazid and Vitamin B6 in its title.

Pyridoxine supplementation during isoniazid therapy.

Tubercle · 1980 · PMID 6269259

ReviewHuman subjects

“The reported frequency of INH-induced neuropathy in various studies is reviewed and population groups at relatively high risk of developing this complication are identified. The routine use of pyridoxine supplementation to prevent peripheral neuropathy in high risk populations is recommended.”

Snider · From the abstract

Names both Isoniazid and Vitamin B6 in its title.

ISONIAZID AND VITAMIN B6

Le Poumon et le coeur · 1964 · PMID 14141250

Review

Names both Isoniazid and Vitamin B6 in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Isoniazid, Vitamin B6, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.