Supplement × Prescription·a synergy·Strong evidence
Isoniazid functionally antagonizes pyridoxine and can cause peripheral neuropathy; vitamin B6 supplementation prevents this in at-risk patients.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Isoniazid functionally antagonizes pyridoxine and can cause peripheral neuropathy; vitamin B6 supplementation prevents this in at-risk patients.
Mechanism. Isoniazid forms inactive hydrazones with pyridoxal phosphate and increases pyridoxine loss.
Recommendation. Use pyridoxine as prescribed, especially in pregnancy, diabetes, HIV, kidney disease, malnutrition, alcohol use, or neuropathy risk.
Effect on the composite score
If both Isoniazid and Vitamin B6 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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