From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Vitamin B6 may help correct low pyridoxal phosphate status associated with long-term theophylline therapy.
Mechanism. Replacement of a potentially depleted cofactor involved in neurotransmitter metabolism.
Recommendation. Use standard supplemental doses unless a clinician directs higher therapy; persistent neurologic symptoms require theophylline level assessment.
Stack Score
How it moves the number.
Effect on the composite score
If both Theophylline and Vitamin B6 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Merrill AH et al. Effect of theophylline therapy on vitamin B6 status. American Journal of Clinical Nutrition. 1980.Needs sourceNo link