NutriStack
L-Tyrosine and Vitamin B6, a synergy.
Vitamin B6 (PLP) is a required cofactor for tyrosine hydroxylase, which converts L-tyrosine to L-DOPA in the dopamine synthesis pathway.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Tyrosine and Vitamin B6
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Vitamin B6 (PLP) is a required cofactor for tyrosine hydroxylase, which converts L-tyrosine to L-DOPA in the dopamine synthesis pathway.
Mechanism. Tyrosine hydroxylase requires tetrahydrobiopterin and iron as cofactors, and the downstream AADC (DOPA decarboxylase) requires PLP (B6) to convert L-DOPA to dopamine.
Recommendation. Take B6 with L-tyrosine to support efficient dopamine production.
Sources (1)
- Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr. 2007
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Tyrosine and Vitamin B6 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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