What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Hydralazine + Vitamin B6 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Hydralazine and Vitamin B6, a synergy.

Q: Can I take Hydralazine and Vitamin B6 together?

Yes. The combination of Hydralazine and Vitamin B6 produces a measurable benefit. Long-term hydralazine can interfere with vitamin B6 biology and has caused pyridoxine-deficiency neuropathy in case reports. Vitamin B6 can help prevent or correct deficiency-related nerve symptoms when hydralazine is the cause. Very high-dose B6 can also cause neuropathy, so replacement should stay in a conservative range unless supervised.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Long-term hydralazine can interfere with vitamin B6 biology and has caused pyridoxine-deficiency neuropathy in case reports. Vitamin B6 can help prevent or correct deficiency-related nerve symptoms when hydralazine is the cause. Very high-dose B6 can also cause neuropathy, so replacement should stay in a conservative range unless supervised.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Hydralazine and Vitamin B6
Pair type: Synergy
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. Long-term hydralazine can interfere with vitamin B6 biology and has caused pyridoxine-deficiency neuropathy in case reports. Vitamin B6 can help prevent or correct deficiency-related nerve symptoms when hydralazine is the cause. Very high-dose B6 can also cause neuropathy, so replacement should stay in a conservative range unless supervised.

Mechanism. Hydralazine can react with pyridoxal and pyridoxal-5-phosphate, reducing availability of the active B6 cofactor for neurologic metabolism. Vitamin B6 replacement restores cofactor availability when deficiency contributes to symptoms.

Recommendation. If you take hydralazine long term, ask your prescriber whether low-dose vitamin B6 is appropriate, especially if you develop numbness, tingling, burning, or poor dietary intake. Avoid chronic high-dose B6 unless directed and monitored.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Hydralazine and Vitamin B6 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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