Supplement × Prescription·contraindicated·Moderate evidence
L-tryptophan can increase serotonin precursor availability and may raise serotonin syndrome risk with tapentadol.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. L-tryptophan can increase serotonin precursor availability and may raise serotonin syndrome risk with tapentadol.
Mechanism. Increased serotonin synthesis potential plus serotonergic warning context.
Recommendation. Avoid coadministration unless specifically supervised; seek urgent care for serotonin syndrome symptoms.
Effect on the composite score
If both L-Tryptophan and Tapentadol are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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