Supplement × Prescription·a caution·Emerging evidence
Melatonin can add to tapentadol-related sedation, dizziness, falls, and respiratory depression risk.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Melatonin can add to tapentadol-related sedation, dizziness, falls, and respiratory depression risk.
Mechanism. Additive CNS depressant effects can worsen opioid impairment and breathing risk.
Recommendation. Avoid unsupervised use, especially during initiation, dose increases, sleep apnea, lung disease, older age, or other sedatives.
Effect on the composite score
If both Melatonin and Tapentadol are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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