Supplement × Prescription·a conflict·Emerging evidence
Theophylline can worsen insomnia and may counter sleep-promoting strategies such as melatonin.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Theophylline can worsen insomnia and may counter sleep-promoting strategies such as melatonin.
Mechanism. Adenosine receptor antagonism promotes wakefulness and can oppose circadian sleep support.
Recommendation. Address theophylline timing, serum level, and caffeine intake before escalating sleep supplements.
Effect on the composite score
If both Melatonin and Theophylline are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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