Supplement × Prescription·a conflict·Emerging evidence
St. John's Wort may induce drug-metabolizing pathways and make theophylline exposure less predictable.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort may induce drug-metabolizing pathways and make theophylline exposure less predictable.
Mechanism. Enzyme and transporter induction can alter clearance of narrow-therapeutic-index drugs.
Recommendation. Avoid starting or stopping St. John's Wort without clinician-supervised theophylline level monitoring.
Effect on the composite score
If both St. John's Wort and Theophylline are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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