Supplement × Prescription·contraindicated·Strong evidence
St. John's Wort can markedly reduce cyclosporine concentrations and has been associated with transplant rejection.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort can markedly reduce cyclosporine concentrations and has been associated with transplant rejection.
Mechanism. Potent induction of CYP3A4 and P-glycoprotein lowers cyclosporine exposure.
Recommendation. Avoid completely unless a transplant specialist explicitly directs otherwise.
Effect on the composite score
If both Cyclosporine and St. John's Wort are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack