What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Losartan + Magnesium Citrate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Losartan and Magnesium Citrate, a synergy.

Q: Can I take Losartan and Magnesium Citrate together?

Yes. The combination of Losartan and Magnesium Citrate produces a measurable benefit. Magnesium supplementation lowers blood pressure modestly (about 2-3 mm Hg systolic and 2 mm Hg diastolic) when added to antihypertensive medication. Combined with losartan the effect is additive and generally beneficial, though it may produce mild hypotension if blood pressure is already at goal.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Magnesium supplementation lowers blood pressure modestly (about 2-3 mm Hg systolic and 2 mm Hg diastolic) when added to antihypertensive medication. Combined with losartan the effect is additive and generally beneficial, though it may produce mild hypotension if blood pressure is already at goal.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Losartan and Magnesium Citrate
Pair type: Synergy
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Strong evidence

Synergy

What is happening. Magnesium supplementation lowers blood pressure modestly (about 2-3 mm Hg systolic and 2 mm Hg diastolic) when added to antihypertensive medication. Combined with losartan the effect is additive and generally beneficial, though it may produce mild hypotension if blood pressure is already at goal.

Mechanism. Magnesium modulates vascular smooth muscle calcium handling, promotes nitric oxide release, and inhibits angiotensin-induced vasoconstriction. These actions complement AT1 receptor blockade.

Recommendation. Magnesium Citrate 200-350 mg elemental magnesium daily is a reasonable add-on; monitor home blood pressure after starting. Tell your prescriber so your losartan dose can be reviewed. Reduce dose if you develop loose stools.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Losartan and Magnesium Citrate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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