NutriStack
Amlodipine and Magnesium Citrate, a caution.
Magnesium acts as a physiologic calcium-channel modulator and lowers blood pressure by about 2 mmHg systolic and 1.8 mmHg diastolic at supplemental elemental-magnesium doses within standard upper-limit guidance in meta-analysis. Combined with amlodipine, the antihypertensive effect can be additive, occasionally producing hypotension, dizziness, or fatigue in well-controlled patients.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Amlodipine and Magnesium Citrate
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Magnesium acts as a physiologic calcium-channel modulator and lowers blood pressure by about 2 mmHg systolic and 1.8 mmHg diastolic at supplemental elemental-magnesium doses within standard upper-limit guidance in meta-analysis. Combined with amlodipine, the antihypertensive effect can be additive, occasionally producing hypotension, dizziness, or fatigue in well-controlled patients.
Mechanism. Magnesium competes with calcium at vascular smooth muscle calcium channels and promotes endothelial NO release. This action overlaps mechanistically with amlodipine's L-type calcium channel blockade.
Recommendation. If you take amlodipine, magnesium citrate doses of 200-350 mg/day supplemental elemental magnesium are usually safe but check your blood pressure after starting. Reduce or stop magnesium if readings fall below your usual range, and watch for diarrhea, which is more common with the citrate form.
Sources (2)
- Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-33. PMID 27402922
- Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol. 1998;46(2):101-10. PMID 9723817
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amlodipine and Magnesium Citrate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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