NutriStack
Magnesium L-Threonate and Vitamin D3, a synergy.
Magnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium L-Threonate and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Magnesium is essential for vitamin D metabolism. It's required for the enzymes that convert D3 to its active form calcitriol.
Mechanism. Magnesium is a cofactor for CYP2R1 (25-hydroxylase) and CYP27B1 (1-alpha-hydroxylase), the enzymes that convert cholecalciferol to 25(OH)D and then to active 1,25(OH)2D.
Recommendation. Ensure adequate magnesium when supplementing D3. Magnesium deficiency can impair D3 activation.
Sources (2)
- Uwitonze AM, Razzaque MS. Role of magnesium in vitamin D activation and function. J Am Osteopath Assoc. 2018
- Chang MC, Choo YJ. Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis.. Nutrients. 2023. PMID 36771225
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium L-Threonate and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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