What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Ciprofloxacin + Magnesium L-Threonate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Ciprofloxacin and Magnesium L-Threonate, timing-sensitive.

Q: Can I take Ciprofloxacin and Magnesium L-Threonate together?

Yes, if you separate them in time. Ciprofloxacin and Magnesium L-Threonate have a documented timing-sensitive interaction. All forms of supplemental magnesium, including magnesium L-threonate used for cognitive support, chelate ciprofloxacin in the gut and reduce its absorption. The bioavailability reduction can exceed 40 percent. The chelation is driven by free Mg2+, which dissociates from any magnesium salt in the acidic environment of the stomach.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

All forms of supplemental magnesium, including magnesium L-threonate used for cognitive support, chelate ciprofloxacin in the gut and reduce its absorption. The bioavailability reduction can exceed 40 percent. The chelation is driven by free Mg2+, which dissociates from any magnesium salt in the acidic environment of the stomach.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Ciprofloxacin and Magnesium L-Threonate
Pair type: Timing Sensitive
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored timing-sensitive row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Timing Sensitive · Strong evidence

Timing Sensitive

What is happening. All forms of supplemental magnesium, including magnesium L-threonate used for cognitive support, chelate ciprofloxacin in the gut and reduce its absorption. The bioavailability reduction can exceed 40 percent. The chelation is driven by free Mg2+, which dissociates from any magnesium salt in the acidic environment of the stomach.

Mechanism. Mg2+ released from magnesium L-threonate chelates the 3-carboxyl and 4-oxo groups on the fluoroquinolone core, forming insoluble complexes that block enterocyte absorption.

Recommendation. Take ciprofloxacin at least 2 hours before or 6 hours after magnesium L-threonate. Do not combine in the same dose.

Minimum separation. 360

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Ciprofloxacin and Magnesium L-Threonate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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