NutriStack
Melatonin and Reishi, a caution.
Both have sedative properties. Reishi contains triterpenes that modulate GABAergic signaling. Combined with melatonin, may cause excessive drowsiness.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both have sedative properties. Reishi contains triterpenes that modulate GABAergic signaling. Combined with melatonin, may cause excessive drowsiness.
Mechanism. Reishi triterpenes (ganoderic acids) modulate GABA-A receptors and TNF-α-induced sleep signaling. Adding exogenous melatonin on top may cause over-sedation via additive mechanisms.
Recommendation. If combining, start with low doses of both and use only at bedtime. Monitor for excessive sedation.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Melatonin and Reishi are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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