What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Melatonin + Ropinirole pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Melatonin and Ropinirole, a caution.

Q: Can I take Melatonin and Ropinirole together?

Possibly, but with caution. Melatonin and Ropinirole have a documented caution-tier interaction. Ropinirole can cause somnolence and sudden sleep episodes, and melatonin can add sleep-promoting effects. This may be useful for nighttime sleep but can worsen next-day drowsiness, slowed reaction time, and falls. The risk is most important during ropinirole titration, in older adults, and when alcohol or other sedating medicines are also present.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Ropinirole can cause somnolence and sudden sleep episodes, and melatonin can add sleep-promoting effects. This may be useful for nighttime sleep but can worsen next-day drowsiness, slowed reaction time, and falls. The risk is most important during ropinirole titration, in older adults, and when alcohol or other sedating medicines are also present.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Melatonin and Ropinirole
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Ropinirole can cause somnolence and sudden sleep episodes, and melatonin can add sleep-promoting effects. This may be useful for nighttime sleep but can worsen next-day drowsiness, slowed reaction time, and falls. The risk is most important during ropinirole titration, in older adults, and when alcohol or other sedating medicines are also present.

Mechanism. Ropinirole is a dopamine D2-like receptor agonist with a recognized somnolence signal in Parkinson's disease trials. Melatonin promotes circadian sleep signaling through MT1/MT2 receptors, creating an additive pharmacodynamic sedation concern.

Recommendation. Take melatonin only at bedtime and start with a low dose while using ropinirole. Avoid driving or hazardous work if you feel sleepy, and report sudden sleep episodes or new daytime sleepiness. Do not combine this pair with alcohol or extra sleep aids unless your prescriber is supervising it.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Melatonin and Ropinirole are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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