NutriStack
Milk Thistle and Schisandra, a synergy.
Schisandra lignans and milk thistle silymarin both support hepatocyte protection and antioxidant defense, giving complementary hepatoprotective effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Milk Thistle and Schisandra
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Schisandra lignans and milk thistle silymarin both support hepatocyte protection and antioxidant defense, giving complementary hepatoprotective effects.
Mechanism. Schisandra lignans upregulate hepatic antioxidant and glutathione systems while silymarin stabilizes hepatocyte membranes and scavenges free radicals, producing complementary liver protection.
Recommendation. Commonly used together for liver support. If on drugs with a narrow therapeutic window, monitor because both can influence hepatic enzyme activity.
Sources (2)
- Panossian A, Wikman G, Pharmacology of Schisandra chinensis, Journal of Ethnopharmacology, 2008
- Abenavoli L et al, Milk thistle in liver diseases, Phytotherapy Research, 2010
Stack Score
How this pair moves the number.
Effect on the composite score
If both Milk Thistle and Schisandra are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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