NutriStack
Schisandra and Tacrolimus/Cyclosporine, contraindicated.
Schisandra increased tacrolimus AUC by 164% and Cmax by 227%. Potentially fatal in transplant patients.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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At a glance
- Substances
- Schisandra and Tacrolimus/Cyclosporine
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Schisandra increased tacrolimus AUC by 164% and Cmax by 227%. Potentially fatal in transplant patients.
Mechanism. Schisandra lignans potently inhibit CYP3A4 and P-glycoprotein short-term, dramatically increasing tacrolimus/cyclosporine exposure.
Recommendation. Do NOT combine. Schisandra dramatically increases immunosuppressant levels.
Sources (1)
- Schisandra tacrolimus AUC increase 164% PMID 19821648
Stack Score
How this pair moves the number.
Effect on the composite score
If both Schisandra and Tacrolimus/Cyclosporine are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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