NutriStack
Ox Bile and Vitamin D3, a synergy.
Bile is required to absorb fat-soluble vitamin D3, so ox bile can improve uptake of D3 supplements in people with low bile output, such as those without a gallbladder or with cholestasis.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ox Bile and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Bile is required to absorb fat-soluble vitamin D3, so ox bile can improve uptake of D3 supplements in people with low bile output, such as those without a gallbladder or with cholestasis.
Mechanism. Vitamin D3 is lipophilic and requires bile-salt-mediated micelle formation for intestinal absorption, so supplemental ox bile provides bile salts that enhance solubilization and uptake when endogenous bile is insufficient.
Recommendation. Take vitamin D3 with a fat-containing meal, and ox bile alongside if you have impaired fat or bile-dependent absorption. Recheck vitamin D status to confirm improvement.
Sources (2)
- Maislos M, Shany S. Bile salt deficiency and the absorption of vitamin D metabolites. Israel Journal of Medical Sciences, 1987
- Hofmann AF. Bile acids: the good, the bad, and the ugly. News in Physiological Sciences, 1999
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ox Bile and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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