Supplement × Prescription·a caution·Moderate evidence
Rifampin can accelerate vitamin D catabolism during prolonged therapy and may contribute to low vitamin D or bone risk.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Rifampin can accelerate vitamin D catabolism during prolonged therapy and may contribute to low vitamin D or bone risk.
Mechanism. Rifampin induces hepatic enzymes involved in vitamin D metabolism.
Recommendation. Monitor 25-hydroxyvitamin D in prolonged therapy or high-risk patients; supplement based on labs rather than guessing.
Effect on the composite score
If both Rifampin and Vitamin D3 are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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