Supplement × Prescription·a caution·Moderate evidence
Rifampin can alter vitamin K dependent anticoagulation control and prolonged antibiotic therapy may affect vitamin K status.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Rifampin can alter vitamin K dependent anticoagulation control and prolonged antibiotic therapy may affect vitamin K status.
Mechanism. Enzyme induction and gut flora changes can alter vitamin K dependent clotting balance.
Recommendation. Coordinate vitamin K intake and INR monitoring if anticoagulated; do not make abrupt supplement changes.
Effect on the composite score
If both Rifampin and Vitamin K1 are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack