NutriStack
Acitretin and Fish Oil Triple Strength, a synergy.
Concentrated fish oil may help manage triglyceride elevations during acitretin therapy. Evidence comes from systemic retinoid studies and acitretin guidelines emphasizing lipid monitoring rather than from a large acitretin-specific omega-3 trial. The combination is supportive when triglycerides are borderline or mildly elevated.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Acitretin and Fish Oil Triple Strength
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Concentrated fish oil may help manage triglyceride elevations during acitretin therapy. Evidence comes from systemic retinoid studies and acitretin guidelines emphasizing lipid monitoring rather than from a large acitretin-specific omega-3 trial. The combination is supportive when triglycerides are borderline or mildly elevated.
Mechanism. EPA and DHA lower triglycerides by reducing hepatic triglyceride synthesis and VLDL secretion. These effects can partially oppose systemic retinoid-induced triglyceride increases.
Recommendation. If your triglycerides rise while taking acitretin, ask whether a concentrated EPA/DHA product is appropriate. Continue fasting lipid checks and do not use fish oil to justify ignoring high triglycerides. Keep your dermatologist informed about the exact dose.
Sources (2)
- Marsden JR. Effect of dietary fish oil on hyperlipidaemia due to isotretinoin and etretinate. Hum Toxicol. 1987;6(3):219-222. PMID 2954894
- Ormerod AD, Campalani E, Goodfield MJ, et al. British Association of Dermatologists guidelines on the efficacy and use of acitretin in dermatology. Br J Dermatol. 2010;162(5):952-963. PMID 20423353
Stack Score
How this pair moves the number.
Effect on the composite score
If both Acitretin and Fish Oil Triple Strength are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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