NutriStack
Atenolol and Fish Oil Triple Strength, a caution.
Concentrated fish oil products deliver 2-3 g of EPA/DHA per softgel, which produces meaningful blood-pressure reductions on top of atenolol. The combination is generally beneficial but can over-shoot the BP target in well-controlled patients.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Atenolol and Fish Oil Triple Strength
- Pair type
- Caution
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Strong evidence
Caution
What is happening. Concentrated fish oil products deliver 2-3 g of EPA/DHA per softgel, which produces meaningful blood-pressure reductions on top of atenolol. The combination is generally beneficial but can over-shoot the BP target in well-controlled patients.
Mechanism. High-dose EPA/DHA causes vasodilation through enhanced NO production and modulates ion channels. Combined with atenolol's beta1 blockade, the cumulative reduction in systolic and diastolic pressure can be clinically meaningful.
Recommendation. If you take atenolol and start a triple-strength fish oil product, monitor your blood pressure for 2-4 weeks. Have your prescriber re-evaluate the atenolol dose if your readings consistently fall below target.
Sources (2)
- Zhang X, Ritonja JA, Zhou N, Chen BE, Li X. Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2022;11(11):e025071. PMID 35647665
- Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens. 2002;20(8):1493-9. PMID 12172309
Stack Score
How this pair moves the number.
Effect on the composite score
If both Atenolol and Fish Oil Triple Strength are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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