NutriStack
Alpha-GPC and Creatine, a synergy.
Both enhance physical and cognitive performance. Creatine buffers ATP in muscles and brain; Alpha-GPC supports cholinergic signaling and growth hormone release.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Both enhance physical and cognitive performance. Creatine buffers ATP in muscles and brain; Alpha-GPC supports cholinergic signaling and growth hormone release.
Mechanism. Creatine increases phosphocreatine for rapid ATP regeneration in brain and muscle. Alpha-GPC provides choline for ACh synthesis and may stimulate GH release via cholinergic pathways.
Recommendation. Effective performance stack for both cognitive and physical output.
Sources (2)
- Ziegenfuss T et al. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response. J Int Soc Sports Nutr. 2008
- Sagaro GG, Traini E, Amenta F. Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2023. PMID 36683513
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-GPC and Creatine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.