NutriStack
Creatine and Magnesium Citrate, a synergy.
Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Creatine and Magnesium Citrate
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Magnesium is required for creatine kinase enzyme activity, which phosphorylates creatine to phosphocreatine.
Mechanism. Creatine kinase requires Mg-ATP as substrate (not free ATP). Magnesium deficiency impairs the creatine kinase reaction and reduces phosphocreatine stores.
Recommendation. Ensure adequate magnesium when supplementing creatine for optimal ATP buffering.
Sources (1)
- Wallimann T et al. Intracellular compartmentation, structure and function of creatine kinase isoenzymes. Biochem J. 1992
Stack Score
How this pair moves the number.
Effect on the composite score
If both Creatine and Magnesium Citrate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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