What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Amlodipine + Vitamin D3 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Amlodipine and Vitamin D3, a synergy.

Q: Can I take Amlodipine and Vitamin D3 together?

Yes. The combination of Amlodipine and Vitamin D3 produces a measurable benefit. In patients with documented vitamin D deficiency and hypertension, vitamin D supplementation produces a small additional reduction in systolic and diastolic blood pressure on top of standard antihypertensive therapy. In vitamin-D-replete patients, the effect is negligible. Combined with amlodipine, the interaction is generally beneficial and very rarely causes hypotension.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

In patients with documented vitamin D deficiency and hypertension, vitamin D supplementation produces a small additional reduction in systolic and diastolic blood pressure on top of standard antihypertensive therapy. In vitamin-D-replete patients, the effect is negligible. Combined with amlodipine, the interaction is generally beneficial and very rarely causes hypotension.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Amlodipine and Vitamin D3
Pair type: Synergy
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. In patients with documented vitamin D deficiency and hypertension, vitamin D supplementation produces a small additional reduction in systolic and diastolic blood pressure on top of standard antihypertensive therapy. In vitamin-D-replete patients, the effect is negligible. Combined with amlodipine, the interaction is generally beneficial and very rarely causes hypotension.

Mechanism. Vitamin D suppresses renin transcription and improves endothelial function. In deficiency, repletion lowers BP modestly; in sufficiency, the effect is absent.

Recommendation. If you take amlodipine and have low 25-hydroxyvitamin D (<30 ng/mL), supplement vitamin D3 to restore normal levels and monitor blood pressure for 6-12 weeks. The combination is appropriate; routine vitamin D supplementation in vitamin-D-replete patients does not lower BP.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Amlodipine and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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