NutriStack
Artemisinin and CYP3A4 Substrate Medications, a caution.
Artemisinin irreversibly inhibits CYP3A4 (~70%) and CYP2B6. CYP3A4 metabolizes ~50% of all prescription drugs.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Artemisinin and CYP3A4 Substrate Medications
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Artemisinin irreversibly inhibits CYP3A4 (~70%) and CYP2B6. CYP3A4 metabolizes ~50% of all prescription drugs.
Mechanism. Mechanism-based (irreversible) inhibition of CYP3A4 and CYP2B6 by flavonoid/coumarin components.
Recommendation. Review all prescription medications for CYP3A4 metabolism before starting artemisinin.
Sources (2)
- Artemisia annua irreversible CYP3A4/CYP2B6 inhibition PMID 36672740
- Obonyo CO, Were VO, Wamae P, Muok EMO. Efficacy and safety of praziquantel plus artemisinin-based combinations versus praziquantel in the treatment of Kenyan children with Schistosoma mansoni infection: open-label, randomized, head-to-head, non-inferiority trial. Antimicrob Agents Chemother. 2025. PMID 39699212
Stack Score
How this pair moves the number.
Effect on the composite score
If both Artemisinin and CYP3A4 Substrate Medications are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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