From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Both can reduce stress arousal and may cause sedation; ashwagandha also has thyroid-related cautions.
Mechanism. Additive calming effects and overlapping thyroid-medication caution.
Recommendation. Avoid high-dose stacking in thyroid disease or when using sedatives; monitor fatigue and thyroid symptoms.
Stack Score
How it moves the number.
Effect on the composite score
If both Ashwagandha and Lemon Balm are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Noguchi-Shinohara M et al. Melissa officinalis cognition trial. Journal of Alzheimer's Disease. 2022.Needs sourceNo link