Supplement × Supplement·a synergy·Emerging evidence
Both can promote sleepiness and may cause next-day grogginess when combined.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Both can promote sleepiness and may cause next-day grogginess when combined.
Mechanism. Additive sleep-promoting and CNS-calming effects.
Recommendation. Use low doses of each and avoid driving if sedated the next morning.
Effect on the composite score
If both Lemon Balm and Melatonin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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