Interaction databaseSupplement × SupplementReviewed May 2026

Ashwagandha and Tongkat Ali, a synergy.

Tongkat ali raises testosterone in low-T men; ashwagandha lowers cortisol that suppresses testosterone. Combined effect on male hormonal status is additive.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Ashwagandha and Tongkat Ali
Pair type
Synergy
Evidence (highest tier)
Emerging
Source citations
1 source
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Tongkat ali raises testosterone in low-T men; ashwagandha lowers cortisol that suppresses testosterone. Combined effect on male hormonal status is additive.

Mechanism. Tongkat ali stimulates LH-mediated testosterone; ashwagandha attenuates HPA-axis cortisol that otherwise suppresses GnRH and testosterone.

Recommendation. Common male hormonal stack: tongkat ali 200 to 400 mg plus ashwagandha 300 to 600 mg per day. Test baseline testosterone and DHEA-S.

Sources (1)
  1. Lopresti AL et al. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha. Am J Men's Health. 2019

Stack Score

How this pair moves the number.

Effect on the composite score

If both Ashwagandha and Tongkat Ali are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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