Ashwagandha and Tongkat Ali, a synergy.
Tongkat ali raises testosterone in low-T men; ashwagandha lowers cortisol that suppresses testosterone. Combined effect on male hormonal status is additive.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ashwagandha and Tongkat Ali
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Tongkat ali raises testosterone in low-T men; ashwagandha lowers cortisol that suppresses testosterone. Combined effect on male hormonal status is additive.
Mechanism. Tongkat ali stimulates LH-mediated testosterone; ashwagandha attenuates HPA-axis cortisol that otherwise suppresses GnRH and testosterone.
Recommendation. Common male hormonal stack: tongkat ali 200 to 400 mg plus ashwagandha 300 to 600 mg per day. Test baseline testosterone and DHEA-S.
Sources (1)
- Lopresti AL et al. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha. Am J Men's Health. 2019
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ashwagandha and Tongkat Ali are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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