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Supplement × Prescription·Evidence index

Testosterone and Tongkat Ali: what the research found

PubMed indexes 8 records that name Testosterone and Tongkat Ali together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“longifolia supplementation for enhancing testosterone production. Although more research is required before its use in clinical practice, this may represent a safe and promising therapeutic option, particularly in hypogonadal men.”

Leisegang et al. · 2022 · Review or meta-analysis · details

“The combination of Eurycoma longifolia and concurrent training improved erectile function and increased total testosterone levels in men with ADAM.”

Leitão et al. · 2021 · Human study · details

“Supplementation of Physta® at 200 mg was able to increase the serum total testosterone, reduce fatigue and improve the quality of life in ageing men within 2 weeks' time.”

The research

8 studies naming Testosterone and Tongkat Ali.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials.

Medicina (Kaunas, Lithuania) · 2022 · PMID 36013514

Systematic ReviewHuman subjects

“longifolia supplementation for enhancing testosterone production. Although more research is required before its use in clinical practice, this may represent a safe and promising therapeutic option, particularly in hypogonadal men.”

Leisegang et al. · From the abstract

Names both Testosterone and Tongkat Ali in its title.

A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM).

Maturitas · 2021 · PMID 33541567

Randomized Controlled Trial

“The combination of Eurycoma longifolia and concurrent training improved erectile function and increased total testosterone levels in men with ADAM.”

Leitão et al. · Authors' conclusion

Names both Testosterone and Tongkat Ali in its title.

Eurycoma longifolia as a potential alternative to testosterone for the treatment of osteoporosis: Exploring time-mannered proliferative, differentiative and morphogenic modulation in osteoblasts.

Journal of ethnopharmacology · 2017 · PMID 27818256

Comparative StudyAnimal study

“Compared to testosterone, greater potential of EL in promoting the proliferation and osteogenic differentiation of MC3T3-E1 cells provides an in vitro basis for the prevention of male osteoporosis. Thus, we anticipate that EL can be considered as an alternative approach to testosterone replacement therapy (TRT) for the treatment of male osteoporosis.”

Thu et al. · Authors' conclusion

Names both Testosterone and Tongkat Ali in its title.

Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats.

Archives of pharmacal research · 2001 · PMID 11693547

Comparative StudyAnimal study

“longifolia Jack significantly increased (p<0.05) the leavator ani muscle to 58.56+/-1.22, 58.23+/-0.31, 60.21 +/-0.86 and 62.35 +/-0.98 mg/100 g body weight, respectively, when compared with the control (untreated) in the uncastrated intact male rats and 49.23+/-0.82, 52.23+/-0.36, 50.21+/-0.66 and 52.35+/-0.58 mg/100 g body weight, respectively, when compared to control (untreated) in the testosterone-stimulated castrated intact male rats.”

Ang et al. · From the abstract

Names both Testosterone and Tongkat Ali in its title.

Effect of Eurycoma longifolia standardised aqueous root extract-Physta(®) on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study.

Food & nutrition research · 2021 · PMID 34262417

“Supplementation of Physta® at 200 mg was able to increase the serum total testosterone, reduce fatigue and improve the quality of life in ageing men within 2 weeks' time.”

Chinnappan et al. · Authors' conclusion

Names both Testosterone and Tongkat Ali in its title.

Effects of Eurycoma Longifolia Jack Supplementation Combined with Resistance Training on Isokinetic Muscular Strength and Power, Anaerobic Power, and Urinary Testosterone: Epitestosterone Ratio in Young Males.

International journal of preventive medicine · 2019 · PMID 31367282

“The prescribed resistance training program, either with or without ElJ supplementation, improved isokinetic power of the lower limb. Resistance training alone improved relative anaerobic power, whereas combined Eurycoma longifolia Jack and resistance training improved peak power output. ElJ consumption of 200 mg daily for 8 weeks did not affect the urinary T/E ratio.”

Chen et al. · Authors' conclusion

Names both Testosterone and Tongkat Ali in its title.

Effects of standardized quassinoid-rich Eurycoma longifolia extract in a rat model of osteoporosis due to testosterone deficiency: A densitometric, morphometric and biomechanical study.

Journal of X-ray science and technology · 2018 · PMID 29689767

Animal study

“Quassinoid-rich EL extract enables to protect against bone loss due to testosterone deficiency. The protective effect on cortical thickness and biomechanical parameters is comparable to testosterone group.”

Jayusman et al. · Authors' conclusion

Names both Testosterone and Tongkat Ali in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

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