NutriStack
Testosterone and Tongkat Ali, a caution.
Eurycoma longifolia (tongkat ali) significantly raises serum total testosterone in healthy and hypogonadal men in a meta-analysis of five RCTs. Adding it on top of prescribed testosterone has no proven benefit and may amplify androgenic side effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Testosterone and Tongkat Ali
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Eurycoma longifolia (tongkat ali) significantly raises serum total testosterone in healthy and hypogonadal men in a meta-analysis of five RCTs. Adding it on top of prescribed testosterone has no proven benefit and may amplify androgenic side effects.
Mechanism. Tongkat ali quassinoids (eurycomanone) appear to stimulate steroidogenic enzymes (CYP17, 3β-HSD) and free testosterone from SHBG, raising both total and free testosterone. Stacking with exogenous testosterone amplifies androgen burden.
Recommendation. Avoid tongkat ali supplementation while on prescribed testosterone. If you wish to use it, discuss with your prescriber and check hematocrit and PSA. Tongkat ali has also been linked to rare cases of liver injury and an atrial flutter case report.
Sources (2)
- Leisegang K, Finelli R, Sikka SC, Panner Selvam MK. Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina (Kaunas). 2022;58(8):1047. PMID 36013514
- Maheshwari A, Verma N, Swaroop A, et al. Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers. Int J Med Sci. 2017;14(1):58-66. PMID 28138310
Stack Score
How this pair moves the number.
Effect on the composite score
If both Testosterone and Tongkat Ali are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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