NutriStack
Testosterone and Tribulus Terrestris, a caution.
Tribulus terrestris is widely marketed as a testosterone booster, but systematic reviews and meta-analyses generally find no consistent effect on serum testosterone in healthy or hypogonadal men. Layering it on prescribed testosterone is unlikely to add benefit and may complicate side-effect attribution.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Testosterone and Tribulus Terrestris
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Tribulus terrestris is widely marketed as a testosterone booster, but systematic reviews and meta-analyses generally find no consistent effect on serum testosterone in healthy or hypogonadal men. Layering it on prescribed testosterone is unlikely to add benefit and may complicate side-effect attribution.
Mechanism. Tribulus saponins were once hypothesized to raise LH and testosterone, but human RCTs have not confirmed an effect on serum androgens. Effects on libido may be androgen-independent.
Recommendation. Tribulus terrestris does not meaningfully add to prescribed testosterone therapy and is best avoided to keep monitoring clean. If you are using it for libido, discuss alternatives with your prescriber that have stronger evidence.
Sources (2)
- Leisegang K, Finelli R, Sikka SC, Panner Selvam MK. Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina (Kaunas). 2022;58(8):1047. PMID 36013514
- Maheshwari A, Verma N, Swaroop A, et al. Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers. Int J Med Sci. 2017;14(1):58-66. PMID 28138310
Stack Score
How this pair moves the number.
Effect on the composite score
If both Testosterone and Tribulus Terrestris are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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