NutriStack
Ashwagandha and Cannabis (THC-Dominant), a caution.
Both can have sedative and CNS-depressant effects, so concurrent use may increase drowsiness and sedation.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ashwagandha and Cannabis (THC-Dominant)
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both can have sedative and CNS-depressant effects, so concurrent use may increase drowsiness and sedation.
Mechanism. Ashwagandha has reported anxiolytic and mild sedative effects partly via GABAergic modulation, which can add to the sedative CNS effects of THC.
Recommendation. Best avoided together; if combined, monitor for excessive sedation, especially when starting. Do not drive or operate machinery until effects are known, and seek medical advice if combined with other sedatives.
Sources (1)
- Salve J et al, Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults, Cureus, 2019
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ashwagandha and Cannabis (THC-Dominant) are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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