NutriStack
Aspirin Low-Dose and Ginkgo Biloba, a caution.
Ginkgo biloba's potent antiplatelet activity (PAF antagonism) combined with aspirin's COX-1 inhibition creates significant additive bleeding risk. Serious bleeding events including intracerebral hemorrhage have been reported in patients taking both agents. The dual antiplatelet mechanism is particularly concerning.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Aspirin Low-Dose and Ginkgo Biloba
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Ginkgo biloba's potent antiplatelet activity (PAF antagonism) combined with aspirin's COX-1 inhibition creates significant additive bleeding risk. Serious bleeding events including intracerebral hemorrhage have been reported in patients taking both agents. The dual antiplatelet mechanism is particularly concerning.
Mechanism. Aspirin irreversibly inhibits platelet COX-1, reducing thromboxane A2. Ginkgolide B is a potent PAF antagonist that inhibits a separate platelet activation pathway. The combination of COX-1 inhibition and PAF antagonism creates substantial, dual-mechanism platelet inhibition with significant bleeding risk.
Recommendation. Avoid ginkgo biloba while taking aspirin, even at low doses. The combination substantially increases bleeding risk through complementary antiplatelet mechanisms. Inform your prescriber if you use ginkgo supplements.
Sources (3)
- Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology. 1996;46(6):1775-1776. PMID 8649594
- Mousavi SN, Hosseinikia M, Yousefi Rad E, Saboori S. Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials. Phytotherapy Research. 2022. PMID 35781715
- Tabrizi R, Nowrouzi-Sohrabi P, Hessami K et al.. Effects of Ginkgo biloba intake on cardiometabolic parameters in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials. Phytotherapy Research. 2020. PMID 33090588
Stack Score
How this pair moves the number.
Effect on the composite score
If both Aspirin Low-Dose and Ginkgo Biloba are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.